This article will cover all the important information you would want to know about Ipamorelin, such as how it works, possible properties, potential blending, and the best locations to acquire it so you can decide whether or not to use it for your research studies. Therefore, let’s get right into it!

Ipamorelin: What Exactly Is It?

Studies suggest Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) with high GH-releasing potency and potential both in vitro [ii].

Compared to GHRP-2, which has a half-life of 25-55 minutes, this one has a longer half-life of 1.5-2.5 hours. Additionally, research suggests it may cause an increase in overall weight gain, while GHRP-2 and GHRP-6 may be responsible for an increase in lean mass [i].

How Does Ipamorelin Peptide Work?

Ghrelin is a naturally occurring hormone generated by the digestive system’s enteroendocrine cells, most prominently in the stomach. It attaches itself to the receptor for growth hormone secretagogues known as GHS-R1a [iii].

The hypothalamus’s agouti-related protein (AgRP)/neuropeptide Y (NPY) neurons are the cells in the brain where the GHSR1a gene is expressed at the highest levels. In locations outside the hypothalamus, GHSR1a is most abundantly expressed in the dopaminergic neurons of the hippocampus and the dorsolateral prefrontal cortex. They are critical for glucose-insulin homeostasis, gastrointestinal motility, cardiovascular health, inflammation, and tissue development and repair [iv], and they may be found in peripheral tissues in adipocytes, cardiomyocytes, and osteoblasts.

Research suggests that Ipamorelin, like GHRP-2, GHRP-6, and Ibutamoren [i], may preferentially bind to the GHSR-1a receptor because it mimics the action of ghrelin. This interaction with GHSR-1a causes the pituitary gland to produce growth hormone, which in turn may impact several anabolic processes, such as the control of hunger, the digestion of fat, and overall energy use [i].

Plasma levels of ACTH and cortisol were suggested to be elevated due to the presentation of both GHRP-6 and GHRP-2. Findings imply Ipamorelin did not seem to cause a substantial change in the quantities of ACTH or cortisol released into the bloodstream after GHRH stimulation [ii], which was a very surprising finding.

Ipamorelin Peptide Properties

Studies suggest that the most important potential of Ipamorelin peptide introduction may be a blood growth hormone (GH) increase. Increased levels of growth hormone (GH) in the blood are solely responsible for the other morphological changes that may be seen in the body.

Research findings imply it may assist in the healing of muscle fibers that have been injured while also efficiently encouraging the creation of new muscle fibers [iv].

Researchers speculate Ipamorelin may promote a speedier and more complete recovery from wounds and traumas by increasing the amount of growth hormone (GH) delivered to the affected region and stimulating the production of new cells.

Previous research on animals suggested that the presentation of Ipamorelin peptide appeared to increase bone mineral content (BMC) in young adult female rats [v].

Scientists hypothesize Ipamorelin may cause an increase in levels of growth hormone (GH), which may contribute to a more restful sleep. It would seem that the release of growth hormone-releasing hormone is the primary factor in determining whether or not GH is secreted during sleep. Growth hormone-releasing hormone presentation may result in less alertness and a greater amount of slow-wave sleep (SWS), as suggested by research conducted on rodents [vi].

After the third decade of life, there is a gradual decrease in GH secretion by roughly 15% for every decade of adult life [vii]. Studies suggest Ipamorelin may be responsible for some increase in natural production.

Ipamorelin vs. Sermorelin

The mechanism of action is where these two peptides diverge significantly from one another.

Research suggests Ipamorelin may bind with growth hormone secretagogue receptors (GHSR) in the hypothalamus and peripheral organs. In contrast, findings imply Sermorelin may bind with growth hormone-stimulating hormone receptors (GHSHr) located in the hypothalamus only. Researchers speculate that even though both peptides appear to cause a greater production of growth hormone (GH), the two peptides interact with growth hormone receptors in different ways.

However, scientists hypothesize that synergistically employing both peptides may produce the best possible outcomes.

Ipamorelin vs. CJC-1295

To reiterate, these peptides are often utilized together, yet, there are significant variances in their levels of efficacy. Studies suggest Ipamorelin may have a relatively quick onset of action, while the effects of CJC-1295 appear not to become apparent for one to four hours. Another disadvantage is that Ipamorelin has a shorter half-life than CJC-1295 [viii].

A scientist interested in studying these compounds can find peptides for sale online at Core Peptides.

References

  • [i] Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020 Mar;9(Suppl 2):S149-S159. doi: 10.21037/tau.2019.11.30. PMID: 32257855; PMCID: PMC7108996.
  • [ii] Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61. doi: 10.1530/eje.0.1390552. PMID: 9849822.
  • [iii] Pradhan G, Samson SL, Sun Y. Ghrelin: much more than a hunger hormone. Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):619-24. doi: 10.1097/MCO.0b013e328365b9be. PMID: 24100676; PMCID: PMC4049314.
  • [iv] Gross JD, Kim DW, Zhou Y, Jansen D, Slosky LM, Clark NB, Ray CR, Hu X, Southall N, Wang A, Xu X, Barnaeva E, Wetsel WC, Ferrer M, Marugan JJ, Caron MG, Barak LS, Toth K. Discovery of a functionally selective ghrelin receptor (GHSR1a) ligand for modulating brain dopamine. Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2112397119. doi: 10.1073/pnas.2112397119. Epub 2022 Mar 3. PMID: 35239443; PMCID: PMC8915830.
  • [v] Svensson J, Lall S, Dickson SL, Bengtsson BA, Rømer J, Ahnfelt-Rønne I, Ohlsson C, Jansson JO. The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats. J Endocrinol. 2000 Jun;165(3):569-77. doi: 10.1677/joe.0.1650569. PMID: 10828840.
  • [vi] Van Cauter E, Plat L. Physiology of growth hormone secretion during sleep. J Pediatr. 1996 May;128(5 Pt 2):S32-7. doi: 10.1016/s0022-3476(96)70008-2. PMID: 8627466.
  • [vii] Garcia JM, Merriam GR, Kargi AY. Growth Hormone in Aging. [Updated 2019 Oct 7]. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279163/
  • [viii] https://www.usada.org/spirit-of-sport/education/6-things-know-peptide-hormones/

 

Categories: Health

Nicolas Desjardins

Hello everyone, I am the main writer for SIND Canada. I've been writing articles for more than 12 years and I like sharing my knowledge. I'm currently writing for many websites and newspapers. I always keep myself very informed to give you the best information. All my years as a computer scientist made me become an incredible researcher. You can contact me on our forum or by email at [email protected].